AUTHOR=Savage Kristina , Williams Joni S. , Garacci Emma , Egede Leonard E. 

TITLE=Association Between Cardiovascular Disease Risk Factors and Mortality in Adults With Diabetes: A Stratified Analysis by Sex, Race, and Ethnicity

JOURNAL=International Journal of Public Health

VOLUME=Volume 67 - 2022

YEAR=2022

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2022.1604472

DOI=10.3389/ijph.2022.1604472

ISSN=1661-8564

ABSTRACT=Evidence suggests modifiable cardiovascular disease (CVD) risk factors are associated with mortality in adults with diabetes, and this relationship differs by sex and race/ethnicity. Data were analyzed from 3,503 adults with diabetes from the National Health and Nutrition Examination Survey (NHANES) 2001-2010 and its linked mortality data through December 31, 2011. The outcome was mortality; the independent variables were sex and race/ethnicity. Cox proportional hazards regression was used to test the association between mortality and the following CVD risk factors: hemoglobin A1c (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein-cholesterol (LDL-C), and body mass index (BMI).
In adjusted analyses, the association between DBP and mortality was significantly different by sex and race (unadjusted p=0.009; adjusted p=0.042). Kaplan-Meier survival curves showed Hispanic women had the highest survival compared to Hispanic men and both men and women in Non-Hispanic Black (NHB) and Non-Hispanic White (NHW) groups; NHW men had the lowest survival probability. Women had higher survival rates compared to men within each race/ethnicity group, and Hispanic women had the highest survival compared to all other groups.