AUTHOR=Yang Chan , Liu Xiaowei , Dang Yuanyuan , Li Juan , Jing Jingyun , Tian Di , Qiu Jiangwei , Zhang Jiaxing , Yan Ni , Liu Xiuying , Zhao Yi , Zhang Yuhong 

TITLE=Obesity Metabolic Phenotype, Changes in Time and Risk of Diabetes Mellitus in an Observational Prospective Study on General Population

JOURNAL=International Journal of Public Health

VOLUME=Volume 67 - 2022

YEAR=2022

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2022.1604986

DOI=10.3389/ijph.2022.1604986

ISSN=1661-8564

ABSTRACT=Objectives: To evaluate the distribution and changes in different obesity metabolic phenotypes, as well as their impact on the incidence of type 2 diabetes mellitus in a northwest Chinese population sample.
Methods: Data comes from prospective cohort study (n= 1393, mean follow up= 9.46 year).  Participants were classified into four groups through a combination of the Chinese Diabetes Society diagnostic criteria for metabolic syndrome with anthropometric measurements. Cox regression models with time-dependent covariates were used to evaluate changes in obesity metabolic phenotypes and risk of T2DM.
Results: Participants in MUO state had the highest risk of developing T2DM, the incidence density was 12.10/1000 person-year. The MHO and MUO groups showed an increased risk of incident diabetes based on body mass index (HR, 1.29; 95% CI, 1.03-1.61; P=0.026 and HR, 1.20; 95% CI, 1.02-1.40; P=0.024 respectively.) Besides, the MHO group had an increased risk of incident diabetes based on waist circumference (HR, 1.41; 95% CI, 1.10-1.80; P=0.006).
Conclusions: Diabetes is more frequent in the MHO and MUO groups and co-occurrence of obesity and metabolic abnormalities contributes to the development of T2DM.