AUTHOR=Song Yumeng , Li Xin , Li Chaoxiu , Xu Shuang , Liu Yong , Wu Xiaomei TITLE=What Are the Effects of Electronic Cigarettes on Lung Function Compared to Non-Electronic Cigarettes? A Systematic Analysis JOURNAL=International Journal of Public Health VOLUME=Volume 67 - 2022 YEAR=2022 URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2022.1604989 DOI=10.3389/ijph.2022.1604989 ISSN=1661-8564 ABSTRACT=Objective: The effect of e-cigarette on lung function was studied from three aspects of lung ventilation, diffusion ability and flow resistance, and compared with non-e-cigarette group. Method: As of March 1st, 2022, relevant literature was selected from four databases through the retrieval strategy, strict literature screening and quality evaluation were conducted. The study followed PRISMA guidelines. Result: Our results showed that CO (SMD: -1.48, 95%: -2.82--0.15) and FeNO (SMD: -0.66, 95%: -1.32, -0.01) was significantly decreased after e-cigarette inhaling. Only asthmatic smokers showed a statistically significant increase in flow resistance after inhaling e-cigarettes . The decrease of FEV1 / FVC% in the non e-cigarette group was more than that in the e-cigarette group (SMD:1.18, 95%: 0.11-2.26). The degree of O2 saturation decrease was also less than the non e-cigarette groups (SMD:0.32, 95%: 0.04-0.59), especially compared to the conventional cigarette group (SMD:0.56, 95%: 0.04-1.08). Conclusion: Combined with the current findings, short-term e-cigarette inhalation has similar but not significant effects on lung function as non-e-cigarettes. More clinical studies are needed to explore the safety of inhaling e-cigarettes, especially in vulnerable populations.