AUTHOR=Feng Hong , Deng Yuan 

TITLE=Human Papillomavirus and Retinoblastoma: Evidence From a Systematic Review and Meta-analysis of Cross-Sectional Studies

JOURNAL=International Journal of Public Health

VOLUME=Volume 68 - 2023

YEAR=2023

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2023.1605284

DOI=10.3389/ijph.2023.1605284

ISSN=1661-8564

ABSTRACT=Objectives: To study the prevalence and the association of HPV infection in retinoblastoma and to determine the most common genotype presented in RB. 
Methods: Following the PRIMSA guideline, 14 studies reporting HPV infection in RB acquired from 6 databases were included. 
Results:The prevalence of HPV from 941 RB samples was 15.6% (95% confidence interval (CI): 7.3-30). Mexico followed by India and Brazil had the highest HPV prevalence in RB samples, 61.7% (95% CI: 17-93), 22.5% (95% CI: 9-47) and 12.1% (95%CI: 2-52), in order. HPV 16 was the most common genotype presented in RB samples 23% (95% CI: 9-47), followed by HPV 18 10% (95% CI: 3-30) and the combined HPV 16-18 6% (95% CI: 0-50). We did not find a significant association between HPV and RB (odds ratio (OR): 12.2; 95% CI: 0.65-232; p= 0.09). However, after removing the largest-weighted study, a significant association between HPV and RB was observed (OR: 45.9; 95% CI; 8.6-245; p <0.001). 
Conclusion: HPV 16 was the most prevalent (15%) and presented genotype in RB samples reflecting a strong association between HPV and RB.