AUTHOR=Wang Suixiang , Liu Shan , Nie Zhiqiang , Li Yexin , Li Ke , Liang Huanzhu , Chen Qian , Wen Lin , Xu Huan , Liang Boheng , Qin Pengzhe , Jing Chunxia 

TITLE=Temporal Trends in the Incidence and Mortality of Major Reproductive-Related Cancers in Women in Guangzhou From 2010 to 2020: A Joinpoint and Age-Period-Cohort Study

JOURNAL=International Journal of Public Health

VOLUME=Volume 68 - 2023

YEAR=2023

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2023.1605300

DOI=10.3389/ijph.2023.1605300

ISSN=1661-8564

ABSTRACT=Objective
To understand the temporal trends of cancers incidence and mortality in women in Guangzhou during the past 11 years and provide clues for future research.
Methods
Data were obtained from the Guangzhou cancer and Death Registry. Average annual percentage changes (AAPC) in age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were obtained by jointpoint regression. The age-period-cohort (APC) model was generated to quantify the effects of age, period, and cohort.
Results
The ASIR showed a downward trend in cervical cancer (AAPC = -4.3%) and Ovarian (AAPC = -3,2%) cancers during 2010-2020, and uterine cancer showed an upward trend. The ASMR increased in breast (APC=5.0%) and cervical (APC=8.8%) cancers. The APC model highlights different age, period, and birth cohort effect depending on the cancer site.
Conclusions
ASIRs for cervical and ovarian cancers among women in Guangzhou showed a decreasing trend during the period. The APC model showed mortality for 4 cancers increased with age. Incidence and mortality decreased with increasing birth cohort. Annual reproductive cancer screening is recommended for women of appropriate age to reduce the disease burden.