AUTHOR=Shen Ruihuan , Wang Jia , Wang Rui , Tian Yuqing , Guo Peiyao , Shen Shuhui , Liu Donghao , Zou Tong 

TITLE=The Role of Cancer in the Risk of Cardiovascular and All-Cause Mortality: A Nationwide Prospective Cohort Study

JOURNAL=International Journal of Public Health

VOLUME=Volume 68 - 2023

YEAR=2023

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2023.1606088

DOI=10.3389/ijph.2023.1606088

ISSN=1661-8564

ABSTRACT=Objectives: Evidence on cardiovascular-related and all-cause mortality risks in a wide range of cancer survivors is scarce but needed to inform prevention and management.We performed a nationwide prospective cohort study using information from the Continuous NHANES in the United States and the linked mortality follow-up files, available for public access. A propensity scorematched analysis with a 1:1 ratio was conducted to reduce the baseline differences between participants with and without cancer. The relationship between cancer status and the cardiovascular-related and all-cause mortality risk was examined using weighted Cox proportional hazards regression. Independent stratification analysis and cancer-specific analyses were also performed.The study sample included 44,342 participants, aged 20 to 85, interviewed between 1999-2018. Of these, 4,149 participants had cancer. All-cause death occurred in 6,655 participants, of whom 2,053 died from cardiovascular causes. Propensity-score matching identified 4149 matched pairs of patients . A fully adjusted Cox proportional hazards regression showed that cancer was linked to an elevated risk of cardiovascular-related and all-cause mortality both before and after propensity score matching .Our study confirmed that cancer was linked to cardiovascular-related and all-cause mortality.