AUTHOR=Zhao Yue-Ze , Zhang Wen-Li , Zhang Kai-Wen , He Yong-Qiao , Xue Wen-Qiong , Yang Da-Wei , Diao Hua , Xiao Ruo-Wen , Liao Ying , Wang Qiao-Ling , Jia Wei-Hua , Wang Tong-Min 

TITLE=Sleep Pattern, Lifestyle Pattern, and Risks of Overall and 20 Types of Cancers: Findings From the UK Biobank Cohort

JOURNAL=International Journal of Public Health

VOLUME=Volume 69 - 2024

YEAR=2025

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2024.1607726

DOI=10.3389/ijph.2024.1607726

ISSN=1661-8564

ABSTRACT=Sleep health and other lifestyle behaviors are gaining increasing attention in public health, particularly for cancer prevention, but a comprehensive assessment is lacking.The study included 380,042 UK Biobank participants. A healthy sleep score was constructed based on five sleep factors: chronotype, sleep duration, insomnia, snoring, and daytime dozing.A healthy lifestyle score was constructed based on four lifestyle factors: smoking, alcohol consumption, diet and physical activity. The effect of healthy sleep and lifestyle on cancer risk was examined by Cox proportional hazard models.Both healthy sleep and lifestyle patterns were significantly associated with a reduced risk of overall cancer and specific cancer sites. Participants with healthy sleep and lifestyle patterns had a lower risk of overall cancer (HR= 0.72, 95% CI = 0.68-0.77), liver cancer (HR= 0.53, 95% CI = 0.31-0.90), bladder cancer (HR= 0.61, 95% CI = 0.47-0.79), lung cancer (HR= 0.22, 95% CI = 0.19-0.27), and colorectal cancer (HR= 0.80, 95% CI = 0.66-0.96) compared to those with unhealthy patterns.Our findings highlight the importance of public health education and interventions to improve sleep and other lifestyle behaviours for cancer prevention.