AUTHOR=Ogunsola Olabanjo , Gaydos Laura M. , Ajayi Oluseye , Dieci Maria , Kaonga Nadi , Awolude Olutosin , Ezemelue Priscilla , Staple Tyree , Salami Kabiru , Idigbe Ifeoma , Ezechi Oliver , Flowers Lisa 

TITLE=The CHESS Protocol: A Mixed-Methods Evaluation of an HPV Screening Intervention for Women Living With HIV in Nigeria

JOURNAL=International Journal of Public Health

VOLUME=Volume 70 - 2025

YEAR=2025

URL=https://www.ssph-journal.org/journals/international-journal-of-public-health/articles/10.3389/ijph.2025.1608716

DOI=10.3389/ijph.2025.1608716

ISSN=1661-8564

ABSTRACT=ObjectivesIn this protocol, we describe a planned intervention to adapt the Mother Mentor (MoMent) peer support program for women living with HIV (WLWH). WLWH face a six-fold higher risk of cervical cancer, yet screening and treatment rates remain low in Nigeria.MethodsUsing an implementation science approach, we will engage key stakeholders—including ministries of health, NACA, professional bodies, WLWH, Mentor Mothers, healthcare providers, and development partners (e.g., WHO, US CDC, USAID)—through deliberative democracy to adapt and expand MoMent for home-based HPV screening and follow-up treatment. We will pilot the adapted MoMent HIV+HCC program with 1,500 women in 15 health facilities across Nigeria’s five geopolitical zones. The RE-AIM framework will guide evaluation of reach, adoption, fidelity, effectiveness, and sustainability.ResultsThis study is designed to contribute to WHO’s global strategy to eliminate cervical cancer by improving access to home-based screening and care in low-resource settings.ConclusionFindings will inform national HPV prevention efforts and may drive broader integration into Nigeria’s cervical cancer program.Clinical Trial RegistrationClinicaltrials.gov, identifier NCT06751030.