AUTHOR=Tavakoli Paris P., Vollmer-Conna2 Ute , Hadzi-Pavlovic Dusan , Grimm Michael C.

TITLE=A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration

JOURNAL=Public Health Reviews

VOLUME=Volume 42 - 2021

YEAR=2021

URL=https://www.ssph-journal.org/journals/public-health-reviews/articles/10.3389/phrs.2021.1603990

DOI=10.3389/phrs.2021.1603990

ISSN=2107-6952

ABSTRACT=Objective: Inflammatory bowel diseases (IBDs) are complex chronic inflammatory disorders of the gastrointestinal tract. The aetiology of IBDs (Chron’s disease and Ulcerative colitis) is still poorly understood but thought to be influenced by multiple factors and their interactions. The overarching aim of this review is to evaluate the extent and nature of the interrelationship between these factors with the disease course examined by previous studies which may hold the promise of identifying novel diagnostic, interventions, and therapeutic strategies.
Methods: A search of commonly cited published literature with high quality research methodology was conducted by exploring terms related to the key questions. 
Results: From the available evidence, the Interdependences between multiple bio-psychological elements with IBD disease activity are evident, although it is implausible that a single explanatory model could elucidate the interplay/sequence of effect between such factors and the disease course.
Conclusion: Longitudinal monitoring of IBD patients and integrating data related to bio-psychological factors and their interplay could help to explain how major factors associate leading to exacerbation of symptoms and their impacts on individuals’ disease course.