AUTHOR=Kussainova Zhumakyz , Kulmaganbetov Mukhit , Abiltayev Askar , Bulegenov Tolkyn , Salikhanov Islam 

TITLE=Risk of Infective Endocarditis Following Invasive Dental Procedures: A Systematic Review and Meta-Analysis

JOURNAL=Public Health Reviews

VOLUME=Volume 45 - 2024

YEAR=2025

URL=https://www.ssph-journal.org/journals/public-health-reviews/articles/10.3389/phrs.2024.1607684

DOI=10.3389/phrs.2024.1607684

ISSN=2107-6952

ABSTRACT=The efficacy of antibiotic prophylaxis following invasive dental procedures remains disputed due to insufficient evidence and a lack of clear causal relationships.Objectives This systematic review and meta-analysis aimed to synthesize evidence and determine the association between IE and dental procedures, including invasive and noninvasive procedures.We conducted a systematic search of PubMed, Google Scholar, and Cochrane databases for studies involving procedures such as tooth extraction, scaling, endodontic treatment, oral surgery, and periodontal treatment involving individuals aged ≥15 years. The primary outcome was the incidence of IE following these procedures.An association was found between IE and invasive dental procedures (OR 1.49, 95% CI 1.25-1.76; p<0.00001). Subgroup analysis showed an increased risk of IE following tooth extraction (OR 2.73, 95% CI 1.46-5.11; p=0.002) and oral surgery (OR 6.33, 95% CI 2.43-16.49; p=0.0002) in high-risk patients.Our study found a strong association between invasive dental procedures and increased IE risk, particularly for tooth extraction and oral surgery in high-risk individuals.