AUTHOR=Hwang Soonmyung A. , Singhvi Aditi , Patil Lokesh , Gohari Kimiya , Yitshak Sade Maayan , Colicino Elena , Aldridge Melissa D. , Baccarelli Andrea A. , Kloog Itai , Schwartz Joel , Morrison R. Sean , Wright Robert O. , Bøggild Henrik , Sheidaei Ali , Knobel Pablo 

TITLE=A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus

JOURNAL=Public Health Reviews

VOLUME=Volume 46 - 2025

YEAR=2025

URL=https://www.ssph-journal.org/journals/public-health-reviews/articles/10.3389/phrs.2025.1607355

DOI=10.3389/phrs.2025.1607355

ISSN=2107-6952

ABSTRACT=ObjectivesAs the aging population grows, Alzheimer’s disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD.MethodsWe conducted a systematic review and meta-analysis of studies investigating the association of long-term (≥1 year) noise exposure and ADRD assessed with standardized diagnostic criteria. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Eligible studies reported hazard ratios (HR) or similar effect estimates with confidence intervals.ResultsA multilevel random-effects meta-analysis of six longitudinal studies using 13 effect sizes found a significant association between long-term noise exposure and incident ADRD (HR: 1.15, 95% CI: 1.03–1.28). Interaction effects between noise source and dementia subtype were not statistically significant.ConclusionLong-term noise exposure may contribute to ADRD risk. Heterogeneity between studies highlights the need for standardized exposure assessment and consideration of other environmental factors. Future research should include the exposome approach for identifying environmental drivers of dementia.