ORIGINAL ARTICLE

Int. J. Public Health, 18 March 2024

Volume 69 - 2024 | https://doi.org/10.3389/ijph.2024.1606766

District-Wise Heterogeneity in Blood Pressure Measurements, Prehypertension, Raised Blood Pressure, and Their Determinants Among Indians: National Family Health Survey-5

  • Indian Council of Medical Research-National Centre for Disease Informatics and Research (ICMR-NCDIR), Bengaluru, Karnataka, India

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Abstract

Objective: The objective of the study was to determine the prevalence and determinants of ever-measured blood pressure, prehypertension, and raised blood pressure at national, state and district levels in India.

Methods: We analysed data from the National Family Health Survey (NFHS-5), on 743,067 adults aged 18–54 years. The sample consisted of 87.6% females and 12.4% males. We estimated prevalence rates and determined adjusted odds ratios for various dependent variables related to blood pressure. Geographical variations were visualized on the map of India, and multivariate logistic regression was employed at state and district levels, with significance set at p < 0.05.

Results: The prevalence of ever-measured blood pressure varied widely, from 30.3% to 98.5% across districts, with southern and northern regions showing higher rates. Prehypertension affected 33.7% of the population, with varying prevalence across districts. Raised blood pressure was there in 15.9%, with notably higher rates in southern region (16.8%). Determinants included age, gender, education, wealth, lifestyle, obesity, and blood glucose levels.

Conclusion: These findings demonstrate the subnational variations in blood pressure, can guide evidence-based interventions at the state and district level, towards reducing the burden of raised blood pressure and enhancing overall population health.

Introduction

Noncommunicable diseases (NCDs) are the leading cause of mortality worldwide [1]. It is estimated that 64.9% of all deaths in India are attributed to noncommunicable diseases. Among them, cardiovascular diseases (CVDs) alone contributed to 27.4% of total mortality [2]. Hypertension is a major preventable risk factor for cardiovascular disease (CVD). On a global scale, a substantial number of individuals, i.e., 1.28 billion people, aged between 30 and 79 years were affected by hypertension, with most of them residing in low- and middle-income countries such as India [3]. In 2014, India became the first country to adopt the global NCD action plan and set national NCD targets and indicators. One of the primary targets was to achieve a 25% relative reduction in the prevalence of high blood pressure in individuals aged 18 and above by the year 2025 [4, 5]. As part of this strategy, the country has introduced population-based screening for hypertension, diabetes, cancer of breast (females), cervix and oral cavity [6, 7].

The National Family Health Survey −5 (2019–21) reported that 21% of women and 24% of men aged 15 and over have hypertension and 39% of women and 49% of men have pre-hypertension [8]. According to the National Noncommunicable Disease Monitoring Survey (NNMS, conducted in 2017–18), less than 50% of participants aged 18–49 years, reported having their blood pressure measured at some point, and 28.5% of the respondents were identified as having raised blood pressure. The burden of prehypertension, an intermediate state between normal blood pressure and hypertension, is equally concerning, as it often progresses to full-blown hypertension. The “India State-Level Disease Burden Initiative” highlighted that prehypertension contributed substantially to cardiovascular diseases, warranting urgent attention. Multiple studies have reported the rising prevalence of prehypertension in various regions of the country [912].

Several studies have shown considerable heterogeneity in hypertension prevalence across different states and regions of India [1319]. However, national-level analysis fails to capture disparities within states [20]. India’s district-level administrative structure provides a unique opportunity for comprehensive health assessment and planning. Each district stands as an independent geographical and administrative unit, characterized by its unique amalgamation of health determinants, socio-economic factors, and healthcare provisions. Understanding the prevalence of pre-hypertension and raised blood pressure at the district level, can help in identifying high-risk areas and prioritizing resources accordingly.

Methods

Data Sources

We conducted a secondary analysis of data from the fifth wave of the National Family Health Survey (NFHS-5), covering 707 districts in 28 Indian states and 8 union territories. NFHS-5 employed a two-stage cluster sampling method with rural villages and urban census enumeration blocks as primary units. Data collection occurred in two phases: Phase I from June 17, 2019, to January 30, 2020, covering 17 states and 5 union territories, and Phase II from January 2, 2020, to April 30, 2021, covering 11 states and 3 union territories. High response rates were achieved, with data gathered from 636,699 households (98% response rate), 724,115 women (97%), and 101,839 men (92%). Over 89% of eligible women and 82% of eligible men aged 15 and older underwent blood pressure and random blood glucose measurements. Detailed information is available in the NFHS-5 India report and interviewer manual [8, 21].

Study Participants

The present analysis included adults aged 18–54 years for males and 18–49 years for females, resulting in a final dataset of 743,067 individuals. The sample consisted of 87.6% females and 12.4% males. NFHS-5 sampled more women than men to cover more of maternal and child health indicators. Males were randomly subsampled from 15% of eligible households (state module) but were representative at national, state and district level. The average age (mean ± standard deviation) of male respondents was 34 ± 10 years, while female respondents had an average age of 32 ± 9 years. The overall sample had an average age of 32 ± 9 years.

Main Outcomes and Variable Definitions

The main objective of this study, conducted as a secondary analysis of NFHS-5 data, was to evaluate district-wise variations in the proportions of individuals with ever-measured blood pressure, as well as to assess the prevalence of prehypertension, raised blood pressure, and their underlying determinants in India.

Dependant Variables

Participants’ blood pressure was measured using an OMRON TM BP monitor, with three readings taken, each with a 5-min interval and a 5-min break before the first reading. The average of the last two readings was used for analysis, and if only one reading was available, it was considered for analysis (3%). Based on standard recommendations of the World Hypertension League Expert Committee raised blood pressure was defines as, systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg or both on the day of survey or who reported currently taking medication for the treatment of high blood pressure, or who report having been diagnosed with hypertension by a health professional [22]. Furthermore, prehypertension was defined as an average systolic blood pressure (SBP) between 120 and 140 mmHg, or an average diastolic blood pressure (DBP) between 80 and 90 mmHg. “Ever measured” indicated individuals whose blood pressure had been assessed by a healthcare provider at least once in their lifetime.

Independent Variables (Determinants)

Socio-demographic factors: Age, sex, marital status, rural or urban residence, religion, household wealth index, education, employment.

Behavioral risk factors: Tobacco and alcohol consumption.

Anthropometric and metabolic factors: BMI categories for the Asian population: underweight (18.5 kg/m2), normal (18.5–22.9 kg/m2), overweight (23–24.9 kg/m2), and obese (25 kg/m2) [23, 24]. Individuals with waist circumference values > 90 cm for men and> 80 cm for women were considered to have central obesity [24] (Supplementary Table S13: Operational definitions).

An individual was classified as having raised blood glucose if random blood glucose level >200 mg/dL on the day of the survey [25]. Biologically implausible biomarker values: SBP below 70 mmHg or above 240 mmHg, DBP below 40 mmHg or above 150 mmHg, or random blood glucose below 40 mg/dL [16, 26] were excluded, If any of the variables needed to define an indicator were not available, we set the respective indicator to missing.

Statistical Analysis

We conducted an analysis using data from NFHS-5, focusing on participants aged 18 years and older, and incorporated individual sampling weights. Our study explored the relationships between several dependent variables: ever-measured blood pressure, prehypertension prevalence, and raised blood pressure, in relation to various determinants. Our approach involved determining sample sizes N), estimating prevalence rates with 95% confidence intervals (CIs), and calculating adjusted odds ratios (AORs) with their respective 95% CIs.

We went beyond estimating proportions and visualized the data on a color-coded map of India, categorizing it into ranges based on prevalence distributions across all districts. This visualization enabled straightforward geographical comparisons. We employed multivariate logistic regression analysis at both state and district levels and set statistical significance at p < 0.05. Our results were presented in tabular form, highlighting factors associated with either “Higher odds” H) or “Lower odds” L) based on the odds ratios. For data analysis, we utilized SPSS software version 27 and employed a data wrapper for visualization purposes.

Results

Sample Characteristics

Table 1 outlines sociodemographic characteristics. Females accounted for 87.6%, while males comprised 12.4% of the sample. The majority were in the 18–34 age group (58.5%), and 46.6% had completed secondary education. Employment was reported by 14.3%, primarily among males. Hindus made up 81.3% of the participants. In terms of wealth, the richest quintile constituted 20.7%, and the poorest 17.8%. Marriage was prevalent (78.4%), and 66.7% resided in rural areas. Tobacco use was reported by 9.3%, with 44% being males. Alcohol consumption was reported by 3.8%, primarily among males (24.9%). BMI was normal for the majority (41.2%), while central obesity affected 55.4% of the population. Normal blood glucose levels were observed in 92.2% of the population.

TABLE 1

Characteristic Male n (%) Female n (%) Total n (%)
Overall 91,900 (12.4) 651,167 (87.6) 743,067 (100)
Age Group
18–34 48,134 (52.4) 386,564 (59.4) 434,698 (58.5)
35–49 35,071 (38.2) 264,603 (40.6) 299,674 (40.3)
50–54 8,695 (9.5) - 8,695 (1.2)
Education
No Education 11,690 (12.7) 159,904 (24.6) 171,594 (23.1)
Primary 11,707 (12.7) 81,279 (12.5) 92,986 (12.5)
Secondary 48,913 (53.2) 297,118 (45.6) 346,031 (46.6)
Higher 19,589 (21.3) 112,865 (17.3) 132,455 (17.8)
Occupation
Unemployed 15,428 (16.8) 67,092 (10.3) 82,520 (11.1)
Employed 76,472 (83.2) 30,112 (4.6) 106,584 (14.3)
Religion
Other 2,444 (2.7) 18,632 (2.9) 21,076 (2.8)
Hindu 73,085 (79.5) 530,978 (81.5) 604,063 (81.3)
Muslim 13,898 (15.1) 86,033 (13.2) 99,931 (13.4)
Christian 2,473 (2.7) 15,524 (2.4) 17,997 (2.4)
Household wealth quintile
Poorest 14,905 (16.2) 116,995 (18) 131,901 (17.8)
Poorer 17,773 (19.3) 128,097 (19.7) 145,870 (19.6)
Middle 19,631 (21.4) 133,582 (20.5) 153,213 (20.6)
Richer 20,755 (22.6) 137,313 (21.1) 158,068 (21.3)
Richest 18,836 (20.5) 135,180 (20.8) 154,016 (20.7)
Marital status
Others 28,193 (30.7) 132,651 (20.4) 160,845 (21.6)
Currently married 63,707 (69.3) 518,515 (79.6) 582,222 (78.4)
Regions of India
Central region 10,456 (11.4) 164,273 (25.2) 174,729 (23.5)
Northern region 7,471 (8.1) 86,446 (13.3) 93,917 (12.6)
Eastern region 23,292 (25.3) 146,359 (22.5) 169,650 (22.8)
Western region 22,356 (24.3) 93,293 (14.3) 115,649 (15.6)
Southern region 23,279 (25.3) 136,597 (21.0) 159,876 (21.5)
North Eastern Region 5,047 (5.5) 24,199 (3.7) 29,246 (3.9)
Place Of Residence
Rural 59,214 (64.4) 436,328 (67) 495,542 (66.7)
Urban 32,686 (35.6) 214,839 (33) 247,525 (33.3)
Tobacco consumption
No 51,509 (56) 622,317 (95.6) 673,826 (90.7)
Yes 40,391 (44) 28,850 (4.4) 69,241 (9.3)
Alcohol consumption
No 69,001 (75.1) 645,884 (99.2) 714,886 (96.2)
Yes 22,899 (24.9) 5,283 (0.8) 28,181 (3.8)
BMI
Normal 36,693 (39.9) 269,464 (41.4) 306,157 (41.2)
Underweight 10,344 (11.3) 97,802 (15) 108,147 (14.6)
Overweight 16,205 (17.6) 93,953 (14.4) 110,158 (14.8)
Obese 21,767 (23.7) 161,911 (24.9) 183,679 (24.7)
Central obesity
Present 65,147 (70.9) 346,799 (53.3) 411,946 (55.4)
Absent 19,952 (21.7) 276,112 (42.4) 296,064 (39.8)
Blood glucose level
Normal 81,575 (88.8) 603,505 (92.7) 685,080 (92.2)
Raised 2,232 (2.4) 9,479 (1.5) 11,711 (1.6)

Sample characteristics of analysed individuals (%) (National Family Health Survey-5, India, 2019–2021).

The population was distributed across various regions of India, with the Central region having the largest representation, encompassing 23.5% (174,729 individuals) of the population. Following closely was the eastern region, comprising 22.8% (169,650 individuals). The southern region constituted 21.5% (159,876 individuals), while the northern, western, and northeastern regions made up 12.6% (93,917 individuals), 15.6% (115,649 individuals), and 3.9% (29,246 individuals) of the population, respectively.

Prevalence and Determinants of Ever Measured Blood Pressure in India From NFHS 5 Survey

The prevalence of ever-measured blood pressure among individuals in India was 66.7%, revealing significant regional disparities ranging from 30.3% to 98.5% across districts. The southern region led with the highest average prevalence rate of 75.8%, with standout UT/states including Lakshadweep (90.8%), Kerala (88.5%), Tamil Nadu (83.3%), and Puducherry (83.2%). The northern region also showed relatively high average prevalence rate of 69.6%, particularly notable in Chandigarh (82.6%), Punjab (82.5%), Delhi (81.9%), Haryana (78.1%), and Himachal Pradesh (76.5%). In contrast, comparatively lower prevalence rates were noted in certain regions and states, such as Madhya Pradesh (62.4%) and Chhattisgarh (62.3%) in the central region, Rajasthan (58.3%) in the north, Odisha (55.5%) and Jharkhand (59.8%) in the east, Gujarat (58.0%) in the west, and Nagaland (57.5%) in the northeast (Table 2).

TABLE 2

Regions State name Ever measured blood pressure (%) Pre - hypertension (%) Raised blood pressure (%)
Central region Uttarakhand 74.1 (72.9–75.3) 35.3 (34.0–36.5) 17.4 (16.5–18.4)
Uttar Pradesh 63.9 (63.6–64.2) 35.2 (34.9–35.5) 17.2 (16.9–17.4)
Chhattisgarh 62.3 (61.5–63.0) 38.8 (38.0–39.5) 17.6 (17.0–18.2)
Madhya Pradesh 62.4 (61.9–62.9) 35.5 (35.0–36.0) 14.3 (13.9–14.6)
Overall Central Region 63.7 (63.5–64.0) 35.6 (35.4–35.8) 16.5 (16.4–16.7)
Northern region Jammu and Kashmir 71.6 (70.5–72.6) 45.2 (44.1–46.4) 13.3 (12.6–14.1)
Himachal Pradesh 76.5 (75.2–77.8) 35.3 (33.9–36.8) 16.7 (15.6–17.8)
Punjab 82.5 (81.9–83.2) 32.2 (31.5–33.0) 25.8 (25.1–26.5)
Chandigarh 82.6 (79.2–85.8) 28.6 (25.1–32.5) 19.4 (16.3–22.7)
Haryana 78.1 (77.4–78.9) 36.6 (35.8–37.5) 18.2 (17.6–18.9)
NCT Of Delhi 81.9 (81.1–82.6) 35.2 (34.3–36.1) 18.6 (17.8–19.3)
Rajasthan 58.3 (57.8–58.8) 43.5 (43.0–43.9) 12.7 (12.3–13.0)
Ladakh 72.3 (63.9–79.3) 48.8 (40.1–57.0) 18.1 (12.3–25.4)
Overall Northern Region 69.6 (69.3–69.9) 39.4 (39.0–39.7) 16.6 (16.4–16.8)
Eastern region Bihar 62.7 (62.3–63.1) 26.5 (26.2–26.9) 17.6 (17.3–17.9)
West Bengal 64.8 (64.4–65.2) 32.3 (32.0–32.7) 13.3 (13.1–13.6)
Jharkhand 59.8 (59.0–60.5) 38.1 (37.4–38.8) 15.2 (14.7–15.7)
Odisha 55.5 (54.9–56.2) 34.4 (33.8–35.1) 17.2 (16.8–17.7)
Overall Eastern Region 62.2 (62.0–62.4) 31.1 (30.9–31.3) 15.6 (15.4–15.8)
Western region Gujarat 58.0 (57.5–58.5) 35.5 (35.0–36.0) 12.9 (12.6–13.2)
Dadra and Nagar Haveli and Daman and Diu 71.1 (65.9–76.1) 37.0 (31.8–42.5) 10.1 (7.2–13.9)
Maharashtra 64.5 (64.1–64.8) 34.5 (34.2–34.8) 13.8 (13.6–14.1)
Goa 85.8 (83.7–87.8) 21.0 (18.8–23.4) 12.8 (11.0–14.8)
Overall Western Region 62.5 (62.3–62.8) 34.7 (34.4–35.0) 13.5 (13.3–13.7)
Southern region Andhra Pradesh 74.7 (74.2–75.2) 29.8 (29.3–30.3) 16.6 (16.2–17.0)
Karnataka 61.5 (61.1–62.0) 30.7 (30.2–31.1) 16.2 (15.9–16.6)
Lakshadweep 90.8 (80.2–96.9) 40.1 (26.0–53.5) 12.1 (5.6–24.9)
Kerala 88.5 (88.0–88.9) 32.9 (32.2–33.5) 15.5 (15.0–16.0)
Tamil Nadu 83.3 (82.9–83.6) 29.7 (29.3–30.2) 17.9 (17.5–18.3)
Puducherry 83.2 (80.3–86.0) 27.7 (24.5–31.2) 13.1 (10.7–15.8)
Andaman and Nicobar Islands 85.7 (80.8–89.9) 36.9 (30.8–43.2) 18.8 (14.2–24.3)
Telangana 78.0 (77.4–78.6) 28.2 (27.6–28.8) 17.3 (16.8–17.8)
Overall Southern Region 75.8 (75.5–76.0) 30.2 (30.0–30.4) 16.8 (16.6–17.0)
Northeastern Region Sikkim 75.5 (70.7–79.6) 34.6 (30.0–39.5) 29.1 (24.8–33.9)
Arunachal Pradesh 65.1 (61.1–69.0) 42.2 (38.1–46.2) 24.6 (21.3–28.3)
Nagaland 57.5 (54.2–60.8) 40.1 (36.9–43.4) 18.3 (15.8–20.9)
Manipur 84.6 (82.6–86.4) 37.3 (34.8–39.8) 19.5 (17.4–21.6)
Mizoram 80.9 (77.7–83.9) 34.5 (30.9–38.2) 17.3 (14.6–20.5)
Tripura 73.0 (71.2–74.7) 33.8 (31.9–35.6) 17.5 (16.1–19.1)
Meghalaya 61.0 (58.7–63.1) 35.3 (33.2–37.5) 17.0 (15.4–18.7)
Assam 67.0 (66.3–67.6) 35.1 (34.4–35.7) 15.3 (14.8–15.8)
Overall Northeastern Region 68.1 (67.5–68.6) 35.4 (34.8–35.9) 16.3 (15.9–16.7)
Overall, India Total 66.7 (66.6–66.8) 33.7 (33.6–33.8) 15.9 (15.8–16.0)

Measurement of blood pressure and prevalence of prehypertension and raised blood pressure across the states (%) (National Family Health Survey-5, India, 2019–2021).

To enhance data visualization on a color-coded map of India, districts were classified into five groups based on the prevalence of individuals reporting ever-measured blood pressure. The highest category (80.0%–98.5%) included 116 districts (16.4%), while 183 districts (25.9%) fell within the range of 70.1%–80.0%. The majority (27.0%) recorded rates between 60.1% and 70.0%, with 22.2% of districts falling between 50.1% and 60.0%. The lowest range of 30.3%–50.0% was observed in 8.5% of districts. Notably, Mahe in Puducherry had the highest rates of ever-measured blood pressure at 98.5%, while districts like East Garo Hills in Meghalaya (30.3%), Khargone (West Nimar) in Madhya Pradesh (32.2%), North Garo Hills in Meghalaya (33.2%), Alirajpur in Madhya Pradesh (33.8%), and Kodagaon in Chhattisgarh (36.4%) exhibited the lowest rates (Table 3; Figure 1A).

TABLE 3

Prevalence of ever measured blood pressure Prevalence of prehypertension Prevalence of raised blood pressure
Good performers
Sl. No State name District name Percentage (%) State name District name Percentage (%) State name District name Percentage (%)
1 Puducherry Mahe 98.5 Madhya Pradesh Bhopal 15.6 Rajasthan Barmer 4.1
2 Puducherry Yanam 94.2 Bihar Purnia 16.3 Uttar Pradesh Kaushambi 5.1
3 Kerala Kannur 93.6 Bihar Katihar 17 Madhya Pradesh Tikamgarh 5.8
4 Tamil Nadu Tiruppur 93.5 Bihar Vaishali 17.2 Rajasthan Jalor 6.0
5 Tamil Nadu Coimbatore 93.3 Bihar Begusarai 17.6 Madhya Pradesh Agar Malwa 6.2
6 Kerala Kozhikode 92.3 Karnataka Bagalkot 18.6 Gujarat Jamnagar 6.8
7 Kerala Malappuram 92.2 Karnataka Davanagere 19.5 Gujarat Botad 6.9
8 Kerala Wayanad 91.8 Goa North Goa 19.9 Rajasthan Baran 7.2
9 Tamil Nadu Salem 91.6 Bihar Madhepura 20.1 Haryana Gurgaon 7.3
10 Goa South Goa 91.5 Bihar Kishanganj 20.4 Madhya Pradesh Khandwa (East Nimar) 7.5
11 Tamil Nadu Theni 91.4 Madhya Pradesh Agar Malwa 20.7 Rajasthan Jaisalmer 7.5
12 Punjab Gurdaspur 91.1 Bihar Khagaria 20.7 Madhya Pradesh Singrauli 7.7
13 Lakshadweep Lakshadweep 90.8 Karnataka Yadgir 20.9 Rajasthan Jhalawar 7.7
14 Punjab Ludhiana 90.7 Goa Overall Goa 21 Rajasthan Karauli 7.9
15 Kerala Kasaragod 90.5 Tamil Nadu Thiruvallur 21.2 Gujarat Amreli 8.2
16 Tamil Nadu Dindigul 90.3 Telangana Siddipet 21.2 Karnataka Yadgir 8.2
17 Tamil Nadu The Nilgiris 90.3 West Bengal Bankura 21.3 Madhya Pradesh Raisen 8.2
18 Kerala Pathanamthitta 90.2 West Bengal South Twenty-Four Parganas 21.3 Gujarat Surendranagar 8.4
19 Mizoram Aizawl 90.2 Bihar Araria 21.4 Jammu and Kashmir Kathua 8.6
20 NCT Of Delhi Southwest 90.1 Telangana Medak 21.4 Jammu and Kashmir Shupiyan 8.7
Bad performers
Sl. NO State name District name Percentage (%) State name District name Percentage (%) State name District name Percentage (%)
1 Meghalaya East Garo Hills 30.3 Jammu and Kashmir Rajouri 63.4 Sikkim North District 38.6
2 Madhya Pradesh Khargone (West Nimar) 32.2 Meghalaya South Garo Hills 56.8 Punjab Bathinda 38.5
3 Meghalaya North Garo Hills 33.2 Jammu and Kashmir Anantnag 55.8 Punjab Firozpur 35.2
4 Madhya Pradesh Alirajpur 33.8 Rajasthan Barmer 55.3 Sikkim South District 35.0
5 Chhattisgarh Kodagaon 36.4 Ladakh Leh (Ladakh) 54.3 Punjab Faridkot 33.0
6 Chhattisgarh Narayanpur 38.2 Arunachal Pradesh Dibang Valley 53.2 Tamil Nadu Madurai 31.4
7 Meghalaya South Garo Hills 38.9 Uttar Pradesh Hamirpur 52.8 Arunachal Pradesh Dibang Valley 30.5
8 Chhattisgarh Bastar 39.1 Jammu and Kashmir Punch 52.4 Haryana Kurukshetra 30.3
9 Nagaland Tuensang 39.4 Madhya Pradesh Alirajpur 52.3 Uttar Pradesh Gonda 30.2
10 Gujarat Kheda 39.4 Sikkim West District 52.3 Arunachal Pradesh West Siang 29.9
11 Odisha Mayurbhanj 40.0 Jharkhand Gumla 51.8 Arunachal Pradesh Papum Pare 29.8
12 Gujarat Botad 40.9 Meghalaya East Garo Hills 51.7 Punjab Moga 29.4
13 Uttar Pradesh Sant Kabir Nagar 41.1 Uttar Pradesh Shamli 51.6 Arunachal Pradesh Tawang 29.3
14 Meghalaya Southwest Garo Hills 41.2 Rajasthan Banswara 51.5 Arunachal Pradesh Lower Subansiri 29.3
15 Maharashtra Nandurbar 41.6 Rajasthan Udaipur 51.5 Haryana Yamunanagar 29.2
16 Uttar Pradesh Shrawasti 41.8 Puducherry Mahe 51.5 Arunachal Pradesh East Siang 29.1
17 Maharashtra Jalgaon 41.9 Rajasthan Nagaur 51.4 Tamil Nadu Ramanathapuram 29.0
18 Gujarat Dohad 42.0 Arunachal Pradesh Anjaw 51.2 Punjab Gurdaspur 28.7
19 Odisha Nuapada 42.1 Uttar Pradesh Saharanpur 51.1 Arunachal Pradesh Upper Subansiri 28.7
20 West Bengal Puruliya 42.3 Jharkhand Khunti 51.1 Punjab Mansa 28.4

Prevalence (%) of ever measured blood pressure, prehypertension and raised blood pressure among Indian districts (20 Good performers and 20 bad performers) (National Family Health Survey-5, India, 2019–2021).

FIGURE 1

FIGURE 1

(A) District-wise prevalence of ever measured blood pressure among adults in India (heat map) (National Family Health Survey-5, India, 2019–2021). (B) District-wise prevalence of prehypertension among adults in India (heat map) (National Family Health Survey-5, India, 2019–2021). (C) District-wise prevalence of raised blood pressure among adults in India (heat map) (National Family Health Survey-5, India, 2019–2021).

At the national level, various factors were associated with individuals having their blood pressure measured. Individuals over the age of 30 years (aOR 1.38), females (aOR 1.79), literate individuals (aOR 1.24), those belonging to middle or rich household wealth index (aOR 1.31 and aOR 1.55, respectively), married individuals (aOR 2.13), urban residents (aOR 1.23), alcohol consumers (aOR 1.26), overweight or obese individuals, and those with raised blood glucose levels (aOR 1.52), were more likely to have their blood pressure measured compared to their counterparts (Table 4).

TABLE 4

Subgroups Ever measured blood pressure Prehypertension Raised blood pressure
n Prevalence (%) AOR n Prevalence (%) AOR n Prevalence (%) AOR
(95% CI) (95% CI) (95% CI) (95% CI) (95% CI) (95% CI)
Overall 707,843 66.7 (66.6–66.8) 743,067 33.7 (33.6–33.8) 743,067 15.9 (15.8–16.0)
Age Group
<30 304,546 59.6 (59.4–59.7) 1 321,205 27.8 (27.6–27.9) 1 321,205 8.2 (8.1–8.3) 1
≥30 403,297 72.1 (72.0–72.2) 1.38 (1.35–1.41) 421,862 38.3 (38.1–38.4) 1.31 (1.28–1.34) 421,862 21.8 (21.7–21.9) 2.35 (2.27–2.43)
Sex
 Male 85,043 54.3 (54.0–54.7) 1 91,900 42.4 (42.1–42.8) 1 91,900 19.2 (18.9–19.4) 1
 Female 622,800 68.4 (68.3–68.5) 1.79 (1.74–1.84) 651,167 32.5 (32.4–32.6) 0.60 (0.58–0.61) 651,167 15.5 (15.4–15.5) 0.72 (0.69–0.75)
Education
Illiterate 165,288 63.5 (63.3–63.7) 1 171,594 37.1 (36.8–37.3) 1 171,594 20.0 (19.8–20.2) 1
Literate 542,555 67.7 (67.5–67.8) 1.24 (1.21–1.28) 571,472 32.7 (32.6–32.8) 0.91 (0.89–0.94) 571,472 14.7 (14.6–14.8) 0.84 (0.81–0.87)
Occupation
Unemployed 77,918 64.8 (64.5–65.2) 1 82,520 33.1 (32.8–33.4) 1 82,520 15.0 (14.7–15.2) 1
Employed 100,019 59.7 (59.4–60.0) 1.01 (0.99–1.04) 106,584 40.4 (40.2–40.7) 1.04 (1.01–1.06) 106,584 19.1 (18.8–19.3) 0.92 (0.89–0.95)
Household wealth quintile 177,937 61.9 (61.7–62.2) 189,104 37.2 (37.0–37.5) 189,104 17.3 (17.1–17.5)
Poorest/Poorer 268,642 59.0 (58.8–59.1) 1 277,770 33.4 (33.2–33.5) 1 277,770 14.8 (14.7–15.0) 1
Middle 147,711 67.2 (67.0–67.5) 1.31 (1.27–1.35) 153,213 33.4 (33.2–33.7) 1.00 (0.97–1.02) 153,213 16.3 (16.2–16.5) 1.11 (1.07–1.15)
Richer/Richest 291,490 73.6 (73.4–73.7) 1.55 (1.51–1.60) 312,083 34.2 (34.0–34.4) 1.08 (1.05–1.11) 312,083 16.7 (16.5–16.8) 1.06 (1.02–1.10)
Marital status
Others 150,108 47.0 (46.8–47.3) 1 160,845 30.0 (29.8–30.3) 1 160,845 10.1 (9.9–10.2) 1
Currently married 557,735 72.0 (71.9–72.1) 2.13 (2.07–2.18) 582,222 34.8 (34.6–34.9) 0.97 (0.94–0.99) 582,222 17.5 (17.4–17.6) 1.19 (1.14–1.23)
Place Of Residence
Rural 478,833 63.9 (63.8–64.0) 1 495,542 33.8 (33.7–33.9) 1 495,542 15.7 (15.6–15.8) 1
Urban 229,009 72.6 (72.4–72.7) 1.23 (1.20–1.26) 247,525 33.6 (33.4–33.8) 1.01 (0.99–1.04) 247,525 16.3 (16.2–16.5) 1.01 (0.98–1.04)
Tobacco consumption
No 641,882 67.7 (67.6–67.8) 1 673,826 33.1 (33.0–33.2) 1 673,826 15.5 (15.4–15.6) 1
Yes 65,961 56.7 (56.3–57.0) 0.79 (0.77–0.82) 69,241 39.5 (39.2–39.9) 1.00 (0.97–1.02) 69,241 20.1 (19.8–20.4) 1.01 (0.97–1.04)
Alcohol consumption
No 681,364 67.0 (66.9–67.1) 1 714,886 33.5 (33.3–33.6) 1 714,886 15.6 (15.5–15.7) 1
Yes 26,479 59.3 (58.7–59.9) 1.26 (1.22–1.30) 28,181 40.7 (40.1–41.3) 0.93 (0.90–0.96) 28,181 24.1 (23.6–24.6) 1.38 (1.32–1.43)
BMI
Normal/Underweight 412,944 60.9 (60.7–61.0) 1 414,304 32.5 (32.3–32.6) 1 414,304 11.8 (11.7–11.9) 1
Overweight/Obese 292,870 74.9 (74.7–75.0) 1.22 (1.19–1.25) 293,837 39.3 (39.1–39.5) 1.21 (1.18–1.24) 293,837 23.5 (23.3–23.6) 1.49 (1.44–1.54)
Central obesity
Absent 410,769 60.3 (60.2–60.5) 1 411,946 33.2 (33.1–33.4) 1 411,946 12.3 (12.2–12.4) 1
Present 295,169 75.5 (75.4–75.7) 1.33 (1.30–1.37) 296,064 38.3 (38.1–38.4) 1.04 (1.01–1.07) 296,064 22.7 (22.6–22.9) 1.63 (1.58–1.68)
Blood glucose level
Normal 683,918 66.4 (66.2–66.5) 1 685,080 35.6 (35.5–35.7) 1 685,080 15.7 (15.6–15.8) 1
Raised 11,691 81.4 (80.7–82.1) 1.52 (1.40–1.65) 11,711 34.6 (33.7–35.4) 0.65 (0.60–0.69) 11,711 44.8 (43.9–45.7) 2.47 (2.31–2.64)

Measurement of blood pressure and prevalence of prehypertension and raised blood pressure and their determinants in Indian population (National Family Health Survey-5, India, 2019–2021).

p value <0.05 is considered statistically significant.

At the state level, age was a significant factor, with individuals aged over 30 years having higher odds of ever measuring blood pressure in 17 states (47.2%). Gender also played a role, with females associated with higher odds in 21 states (58.3%). Education was linked to higher odds in 8 states (22.2%). Household wealth, specifically middle and rich wealth indices, showed positive associations in 11 states (30.6%) and 15 states (41.7%), respectively. Marriage and urban residence were positive factors, with 23 states (63.9%) and 10 states (27.8%) showing higher odds. Alcohol consumption, obesity/overweight, central obesity, and raised blood glucose were associated with higher odds in a few states, ranging from 2 states (5.6%) for alcohol consumption to 15 states (41.7%) for obesity/overweight (detailed in Supplementary Table S7).

Similar patterns were observed at the district level, with age, gender, education, household wealth, marriage, and urban residence serving as significant determinants linked to higher odds of having ever measured blood pressure in various districts. Furthermore, alcohol consumption, obesity/overweight, central obesity, and raised blood glucose showed associations with higher odds, with marriage being the most prevalent factor in28.5% of districts (Detailed in Supplementary Table S10).

Prevalence and Determinants of Prehypertension in India From NFHS-5 Survey

Prehypertension prevalence varied widely across Indian districts, with an overall rate of 33.7% (95% CI: 33.6–33.8), ranging from 15.6% to 63.4%. The Southern region had a lower average prevalence at 30.2%, including Puducherry (27.7%), Telengana (28.2%), Tamil Nadu (29.7%), and Andhra Pradesh (29.8%), with relatively lower rates. The northern region also performed well, with an average rate of 39.4%, with Himachal Pradesh (35.3%) and Chandigarh (28.6%) showing lower rates. Conversely, Jammu and Kashmir (45.2%), Ladakh (48.8%), and Rajasthan (43.5%) in the north, and Chhattisgarh (38.8%) in the central region had higher prehypertension rates (Table 2).

To enhance data visualization on a color-coded map of India, districts were categorized into five groups based on prehypertension prevalence percentages. The highest range (50.1%–63.4%) included 25 districts (3.5%), while 165 districts (23.3%) fell in the 40.1%–50.0% range. The majority, 347 districts (49.1%), had prevalence rates between 30.1% and 40.0%. Prevalence rates between 20.1% and 30.0% were observed in 162 districts (22.9%), with only 8 districts (1.1%) having the lowest range of 15.6%–20.0%. Notably, Bhopal in Madhya Pradesh had the lowest rate at 15.6%, while Rajouri (63.4%) and Anantnag (55.8%) in Jammu and Kashmir had the highest rates. Bihar and Karnataka had the lowest rates in the top 20 districts, while Rajasthan and Jammu and Kashmir had the highest rates in the bottom 20 districts (Table 3; Figure 1B). Detailed district-wise data is available in Supplementary Tables S1–S6.

Various factors were associated with prevalence of prehypertension at the national level. Individuals aged over 30 years had higher odds of being prehypertensive (aOR 1.31), with notably high rates (27.8%) among younger individuals. Higher odds of prehypertension were observed in individuals from wealthier households (aOR 1.08) and those overweight or obese (aOR 1.21).

Conversely, females (aOR 0.60), literate individuals (aOR 0.91), alcohol consumers (aOR 0.93), and individuals with elevated blood glucose levels (aOR 0.65) had lower odds of being prehypertensive compared to their counterparts. There was no statistically significant link between tobacco consumption and the prevalence of prehypertension (Table 4).

Age over 30 was associated with higher odds in several states and districts, while being female was linked to lower odds in many areas. Literacy generally lowered the odds of prehypertension. Employment had mixed effects, with both higher and lower odds observed. Household wealth showed diverse impacts in a few regions. Marriage and urban residence were associated with lower odds in several places. Tobacco and alcohol consumption had varying effects, and obesity, particularly obesity/overweight, was consistently linked to higher odds. Central obesity also showed higher odds in a few districts. Raised blood glucose was associated with lower odds in some areas (detailed in Supplementary Tables S8–S11).

Prevalence and Determinants (Sociodemographic and Behavioural) of Raised Blood Pressure in India From NFHS5 Survey

The prevalence of raised blood pressure in India was found to be 15.9% (95% CI: 15.8–16.0), exhibiting considerable variation across districts, ranging from 4.1% to 51.8%.

The southern region performed relatively better with a lower average raised blood pressure prevalence rate of 16.8%, showcasing states such as Lakshadweep (12.1%), Kerala (15.5%), and Tamil Nadu (17.9%) had lower rates. The northern region also demonstrated lower average prevalence, with an average rate of 16.6%. This region included states like Himachal Pradesh (16.7%), Chandigarh (19.4%), and Delhi (18.6%) which displayed higher rates. Conversely, some regions and states exhibited higher prevalence rates of raised blood pressure. The Northeastern region, with an average prevalence rate of 16.3%, encompassed states like Sikkim (29.1%) and Arunachal Pradesh (24.6%) with higher prevalence rates. States in the Central region showed varying rates, with Madhya Pradesh having a relatively lower prevalence rate (14.3%) (Table 2).

To enhance data visualization on a color-coded map of India, the districts were classified into five groups based on raised blood pressure prevalence percentages. The highest range (25.1%–51.8%) encompassed 129 districts (18.2%), while 85 districts (12.0%) fell in the 20.1%–25.0% range. Most districts, 258 (36.5%), had prevalence rates between 15.1% and 20.0%. Rates of 10.1%–15.0% were observed in 192 districts (27.2%), and 43 districts (6.0%) had the lowest range of 4.1%–10.0%. Among low-prevalence districts, Barmer in Rajasthan had the lowest at 4.1%. Conversely, high-prevalence districts included North and South Districts in Sikkim, Bathinda, Firozpur, and Faridkot in Punjab. Arunachal Pradesh had the most districts [7] among the bottom 20 with high rates, while Rajasthan and Madhya Pradesh had the most (7 and 5, respectively) low-prevalence districts among the top 20 (Table 3; Figure 1C). Detailed district-wise data is available in Supplementary Tables S1–S6.

The prevalence of raised blood pressure at the national level was associated with several determinants. Individuals over the age of 30 years (aOR 2.35) had higher odds of having raised blood pressure; however, the prevalence rate was also high even among younger age groups (8.2%). Belonging to wealthier households (aOR 1.11), being married (aOR 1.19), and consuming alcohol (aOR 1.38) were associated with higher odds of having raised blood pressure. Being overweight or obese (aOR 1.49), having central obesity (aOR 1.63), and having raised blood glucose levels (aOR 2.47) were also associated with higher odds of raised blood pressure. On the other hand, females (aOR 0.72), literate individuals (aOR 0.84), and employed individuals (aOR 0.92) had lower odds of having raised blood pressure. However, no statistically significant link was found between place of residence, tobacco consumption, and the prevalence of raised blood pressure (Table 4).

In the state-level analysis, most states (75.0%) exhibited higher odds of raised blood pressure among individuals over 30 years old. Female gender was associated with lower odds in half of the states (50.0%), while education was linked to lower odds in 22.2%. Employment status predominantly indicated lower odds in 13.9% of states, while the household wealth index showed higher odds in 13.4% (middle) and 11.1% (rich) of states. Marriage correlated with higher odds in 22.2% of states, and urban residence had varying odds in 11.1%. Tobacco consumption had mixed effects, while alcohol consumption was associated with higher odds in 27.8%. Both obesity/overweight and central obesity were associated with higher odds in 58.3% and 63.9% of states, respectively, with raised blood glucose associated with higher odds in 55.6% of states (detailed in Supplementary Table S9).

At the district level, Individuals aged over-30 had higher raised blood pressure odds in 33.0%% of districts. Female gender had lower odds in 14.2%%, education in 6.2%%, and employment had lower odds in 4.5% of districts. Household wealth index had raised odds in 4.5% (middle) and 5.9% (rich) of districts. Married individuals had higher odds in 6.2%, while urban residence varied in 8.0% districts. Alcohol consumption was associated with higher odds in 8.3% of districts, and obesity/overweight and central obesity was associated with higher odds in 17.5% and 17.1%, respectively. Raised blood glucose linked to higher odds in 10.4% of districts (Supplementary Table S12).

Discussion

This study offers crucial insights into the prevalence and determinants of blood pressure measurement, prehypertension and raised blood pressure at national, state, and district levels in India.

Ever measured blood pressure rates, prevalence of prehypertension and raised blood pressure exhibited wide variations across the states and districts. The states of southern region were better performing when compared to others. The regional disparities highlighted in our study are consistent with numerous other studies conducted in India, illustrating similar inter-state and intra-state disparities [18, 19, 2730]. For example, a multilevel analysis conducted in the state of Maharashtra revealed variations in raised blood pressure prevalence across the districts, with rates ranging from 15% in Hingoli to 36% in Mumbai. Districts such as Satara, Dhule, Gadchiroli, and Mumbai have a high blood pressure prevalence of over 30%, while Hingoli, Nagpur, Osmanabad, Wardha, and Akola have a prevalence rate below 20% [27].

These disparities can be attributed to various factors, including differences in healthcare infrastructure, socio-economic conditions, lifestyle choices, and urban-rural divides. Addressing these multifaceted factors is crucial for reducing healthcare disparities and enhancing raised BP-related health outcomes in India, both at the state and district levels.

The study investigated various sociodemographic and behaviour factors linked to blood pressure measurement and the prevalence of prehypertension and raised blood pressure. Age was a significant factor, with older individuals having higher odds of these conditions [19, 28, 3133]. These findings were consistent with prior research, including a repeated cross-sectional analysis conducted using NFHS data [34]. However, there is a growing concern about the rising rates of prehypertension and elevated blood pressure in younger individuals [12, 35, 36]. The health system in India mainly focuses on screening the older adult population [7] and most health promotion efforts target middle-aged and elderly populations. Therefore, there is a need to develop or adopt successful strategies, such as the life course approach, which has been effective in preventing NCDs and emphasizes early screening and diagnosis. Implementing interventions in schools, colleges, and workplaces is crucial for reaching adolescents and younger adults.

Women are more likely to have their blood pressure checked, possibly due to ante-natal care services, and they also have a lower probability of experiencing prehypertension and raised blood pressure [37]. These findings align with previous studies highlighting women’s health-conscious and proactive healthcare-seeking behaviour [37, 38]. In contrast, men tend to exhibit suboptimal health-seeking behaviour, regardless of the specific medical condition [39, 40]. They often seek medical attention only during emergencies or when chronic illnesses have already advanced [41]. Hence encouraging men to seek healthcare proactively is crucial, particularly through health education and opportunistic screening.

Education and wealth played important roles, with higher educational attainment associated with a higher likelihood of blood pressure measurement and a lower likelihood of prehypertension. Wealthier individuals had increased odds of blood pressure measurement, prehypertension and raised blood pressure, which is consistent with findings from previous studies [14, 15, 42]. This reflects the influence of economic status on healthcare access and lifestyle factors.

Urban residents had higher odds of having their blood pressure measured, likely benefiting from improved healthcare access. However the prevalence of raised blood pressure did not vary significantly, which is consistent with some previous study [11]. Conversely, several studies in India have highlighted rural-urban discrepancies in raised blood pressure prevalence [14, 20, 32, 38]. This may indicate a potential narrowing of the urban-rural divide, even concerning other non-communicable diseases and their associated risk factors [43].

Alcohol consumption was associated with higher odds of ever measured blood pressure and raised blood pressure prevalence. General and central obesity, along with raised blood glucose levels, were consistently associated with higher odds of raised blood pressure aligning with numerous studies conducted in India that have examined the impact of alcohol consumption, tobacco use, obesity, and elevated blood glucose levels on ever-measured blood pressure, prevalence of prehypertension, and raised blood pressure [19, 27, 28, 4448].

Despite India’s pioneering role in adopting the global NCD action plan and setting national targets, achieving a 25% relative reduction in high blood pressure prevalence among adults aged 18 and above by 2025 proved challenging. This difficulty was highlighted by the study’s findings of a 10.1% decrease in age-standardized premature mortality rates (ASPMR) and a 9.3% decrease in the underlying potential years of life lost (UPoD) for cardiovascular diseases (CVD) between 2010 and 2025, indicating some progress. However, the lack of significant decline from 2001 to 2019 revealed a failure to meet the WHO’s reduction targets for CVD, resulting in a shortfall of over 15% and 25% respectively, by 2025 [49].

Our study’s identification of district-level variations and specific determinants is vital for policymakers and healthcare providers. It informs targeted interventions for prehypertension and raised blood pressure in India, enabling cost-effective approaches and tailored health policies at state and district levels. Learning from successful districts can uplift care in underperforming areas, enhancing raised blood pressure care nationwide.

The study has several strengths, including its large sample size, standardized data collection, comprehensive assessment, district-level analysis, and inclusion of various determinants. However, it also has some limitations, such as single day measurement of blood pressure, which might have overestimated prevalence of prehypertension and raised blood pressure, alcohol consumption was a significant determinant We have considered data on current alcohol consumption, i.e., who respondent yes to the question do you consume alcohol, from NFHS 5 survey. However, we did not use detailed data on the amount of alcohol, drinking patterns (such as occasional use, abuse, binge drinking), or the type of alcoholic beverage consumed for our analysis, the cross-sectional design hinders establishing causal relationships. Additionally, sampling bias may have excluded certain population groups. Despite these limitations, the study offers a valuable foundation for monitoring raised blood pressure care in India and identifying areas for enhancement.

Conclusion

Our study sheds light on the varying landscape of blood pressure measurement, prehypertension, and raised blood pressure prevalence in India. These variations underscore the urgent need for targeted interventions to address healthcare disparities, especially among vulnerable populations. Strategies should encompass health education, healthcare access, and awareness campaigns, promoting proactive healthcare-seeking behaviour, particularly among men. Factors like age, gender, education, wealth, and urban residence influence these conditions, while factors like alcohol consumption, obesity, and elevated blood glucose levels need attention, highlighting the need for targeted interventions.

Leveraging existing national programs like National Programme for Prevention and Control of Non-Communicable Diseases and Ayushman Arogya Mandir can provide a solid foundation for evidence-based interventions to enhance raised blood pressure care across diverse regions. Aligning efforts with national programs is a crucial approach, and insights from successful districts can guide strategies to uplift underperforming areas, ultimately reducing the burden of raised blood pressure across India’s varied regions.

Statements

Data Availability Statement

Publicly available datasets were analysed in this study. The comprehensive dataset employed in this study can be accessed at: https://www.dhsprogram.com.

Ethics Statement

This study utilized publicly accessible secondary data, and no personally identifiable information about survey respondents is included in the dataset. The Institutional Ethics Committee at ICMR-NCDIR, Bengaluru, approved the study under exemption from review (NCDIR/IEC/3057/2022).

Author Contributions

KS, VK, and PM contributed to the concept, and design of the paper, and were involved in the revision of the manuscript. KS, VK, and RM developed the analysis plan. VK and RM were involved in data management and statistical analyses. KS drafted the manuscript with expert review and inputs from PM and VK. VK was the principal investigator of this non funded project. All authors contributed to the article and approved the submitted version.

Conflict of Interest

The authors declare that they do not have any conflicts of interest.

Supplementary Material

The Supplementary Material for this article can be found online at: https://www.ssph-journal.org/articles/10.3389/ijph.2024.1606766/full#supplementary-material

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Summary

Keywords

prehypertension, blood pressure, determinants, prevalence, India

Citation

Seenappa K, Kulothungan V, Mohan R and Mathur P (2024) District-Wise Heterogeneity in Blood Pressure Measurements, Prehypertension, Raised Blood Pressure, and Their Determinants Among Indians: National Family Health Survey-5. Int J Public Health 69:1606766. doi: 10.3389/ijph.2024.1606766

Received

26 October 2023

Accepted

28 February 2024

Published

18 March 2024

Volume

69 - 2024

Edited by

Licia Iacoviello, Mediterranean Neurological Institute Neuromed (IRCCS), Italy

Reviewed by

Rajendra Gadhavi, B.J. Medical College and Civil hospital, India

One reviewer who chose to remain anonymous

Updates

Copyright

*Correspondence: Prashant Mathur, ; Vaitheeswaran Kulothungan,

†These authors share first authorship

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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